An individual researcher or institution shall apply for and receive approval from the Department before starting research in collaboration with an OADPO program. The Department shall: Review each request; and Approve or disapprove the proposed research based on whether the proposed research: Advances scientific knowledge or practice related to opioid-associated disease prevention and outreach; Has approaches, aims, and methods that will allow the researcher to perform descriptive analyses or test hypotheses; Has one or more investigators who have training and experience with the approaches and methods; Will impede or interfere with the operations of the OADPO program; Is approved by the Department’s Institutional Review Board to ensure that the research will be conducted according to established ethical guidelines for research in the field of opioid-associated disease prevention and outreach; and Will keep any data used for the research confidential as required by: Health-General Article, §24-906(B), Annotated Code of Maryland; 42 U.S.C. §290dd-2; and 42 CFR Part 2.